Fertility preservation in girls with turner syndrome: prognostic signs of the presence of ovarian follicles.
J Clin Endocrinol Metab
; 94(1): 74-80, 2009 Jan.
Article
en En
| MEDLINE
| ID: mdl-18957497
ABSTRACT
CONTEXT Many girls with Turner syndrome have follicles in their ovaries at adolescence. OBJECTIVE:
Our objective was to study which girls might benefit from ovarian tissue freezing for fertility preservation.DESIGN:
Clinical and laboratory parameters and ovarian follicle counts were analyzed among girls referred by 25 pediatric endocrinologists. SUBJECTS ANDSETTING:
Fifty-seven girls with Turner syndrome, aged 8-19.8 yr, were studied at a university hospital.INTERVENTIONS:
Ovarian tissue was biopsied laparoscopically, studied for the presence of follicles, and cryopreserved. Blood samples were drawn for hormone measurements. MAIN OUTCOMEMEASURES:
Presence of follicles in the biopsied tissue related to age, signs of spontaneous puberty, karyotype, and serum concentrations of gonadotropins and anti-Müllerian hormone were assessed.RESULTS:
Ovarian biopsy was feasible in 47 of the 57 girls. In 15 of the 57 girls (26%), there were follicles in the tissue piece analyzed histologically. Six of seven girls (86%) with mosaicism, six of 22 (27%) with structural chromosomal abnormalities, and three of 28 with karyotype 45X (10.7%) had follicles. Eight of the 13 girls (62%) with spontaneous menarche had follicles, and 11 of the 19 girls (58%) who had signs of spontaneous puberty had follicles. The age group 12-16 yr had the highest proportion of girls with follicles. Normal FSH and anti-Müllerian hormone concentrations for age and pubertal stage were more frequent in girls with follicles.CONCLUSIONS:
Signs of spontaneous puberty, mosaicism, and normal hormone concentrations were positive and statistically significant but not exclusive prognostic factors as regards finding follicles.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Síndrome de Turner
/
Fertilidad
/
Folículo Ovárico
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
Idioma:
En
Revista:
J Clin Endocrinol Metab
Año:
2009
Tipo del documento:
Article
País de afiliación:
Suecia