Evaluation of out-in skin transparency using a colorimeter and food dye in patients with atopic dermatitis.
Br J Dermatol
; 160(5): 972-9, 2009 May.
Article
en En
| MEDLINE
| ID: mdl-19222458
ABSTRACT
BACKGROUND:
Atopic dermatitis is a disease of skin barrier dysfunction and outside stimuli can cross the skin barrier.OBJECTIVES:
To examine a new method for evaluating the outside to inside skin transparency with a colorimeter and yellow dyes.METHODS:
In study 1, a total of 28 volunteer subjects (24 normal and four with atopic dermatitis) participated. After provocation with yellow dye, the skin colour of all the subjects was measured using a colorimeter. The skin transparency index was calculated by the changes of the skin colour to yellow. Other variables of skin function, including transepidermal water loss (TEWL) and stratum corneum hydration, were also measured. In study 2, the skin transparency index was evaluated for a cohort of 38 patients with atopic dermatitis, 27 subjects with dry skin and 29 healthy controls.RESULTS:
In study 1, the measurement of skin colour (b*) using tartrazine showed good results. There was a significant relationship between the skin transparency index with tartrazine and the atopic dermatitis score (P = 0.014). No other measurements of skin function, including the TEWL, were correlated. In study 2, the skin transparency index score obtained with tartrazine in the patients with atopic dermatitis was significantly higher than that of the controls and those with dry skin (P < 0.001 and P = 0.022, respectively). However, the TEWL in patients with atopic dermatitis was not significantly higher than that of patients with dry skin and the TEWL in subjects with dry skin was not higher than that of the controls.CONCLUSIONS:
This method, which used a colorimeter and food dye, is noninvasive, safe and reliable for the evaluation of out-in skin transparency and can demonstrate the characteristic dysfunction in the skin barrier in patients with atopic dermatitis.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Piel
/
Tartrazina
/
Dermatitis Atópica
/
Colorantes de Alimentos
Tipo de estudio:
Observational_studies
Límite:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Br J Dermatol
Año:
2009
Tipo del documento:
Article
País de afiliación:
Japón