Role of interferon-gamma on the in vivo expression of functional interleukin-2 receptors by murine macrophages.
Inflammation
; 15(3): 223-31, 1991 Jun.
Article
en En
| MEDLINE
| ID: mdl-1937695
ABSTRACT
Interferon-gamma activates both in vitro and in vivo macrophage functions. Injection of rat recombinant interferon-gamma (rR-IFN-gamma) induced the expression of interleukin-2 receptors (IL-2R) by peritoneal macrophages from normal BALB/c and MRL-+/+ mice. Moreover, rR-IFN-gamma stimulated in a dose-dependent manner the oxidative burst of cells as revealed by luminol-dependent chemiluminescene (LDCL). Resident peritoneal macrophages from MRL-lpr/lpr (mice that develop a systemic lupus-like syndrome) showed a higher PMA-triggered LDCL response. This enhanced activity was accompanied by an increase in IL-2R expression (30% vs. less than 1%). The "activated" macrophages from rR-IFN-gamma-treated normal mice as well as MRL-lpr/lpr mice did not respond to the addition of recombinant interleukin-2 (rHu-IL-2) by an increase in LDCL. However, rHu-IL-2 triggering became efficient when cells enriched in IL-2R-bearing macrophages were preincubated overnight with rHu-IL-2R. This response may point out a functional role for IL-2R and provide a role for IL-2 in certain macrophage functions.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Receptores de Interleucina-2
/
Interferón gamma
/
Macrófagos
Límite:
Animals
Idioma:
En
Revista:
Inflammation
Año:
1991
Tipo del documento:
Article
País de afiliación:
Francia