Study of the P300 and cerebral maps in subjects with multi-infarct dementia treated with cytidine.
Psychopharmacology (Berl)
; 103(1): 1-5, 1991.
Article
en En
| MEDLINE
| ID: mdl-2006235
ABSTRACT
A study of event-related P300 potential and cerebral EEG maps was performed in 20 patients affected by multi-infarct dementia (MID) 10 subjects were treated with placebo and 10 with cytidine. The trial was divided into three intervals. The patients, after a period of washout, were evaluated throughout the course of the trial by electrophysiological examination performed at baseline, after 90 min from the first IV injection, again after 30 days of IM therapy, and finally after 60 days of continued IM therapy. In the group treated with cytidine, the findings relevant to the study of the P300 showed a significant decrease in latency values compared to baseline (P less than 0.05 ANOVA) and an improvement. though not significant, in the amplitude values. Calculation of the mean relative power of EEG values showed a significant decrease in delta activity and an increase in alpha activity. In the subjects treated with placebo, no statistically significant variation was found in either P300 or EEG map recordings. On the basis of these investigations it has been demonstrated that the variations in the registrations can be correlated to the improved neuronal activity following treatment with cytidine.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Mapeo Encefálico
/
Demencia por Múltiples Infartos
/
Citidina
/
Electroencefalografía
/
Potenciales Evocados Somatosensoriales
Tipo de estudio:
Clinical_trials
Límite:
Aged
/
Humans
/
Middle aged
Idioma:
En
Revista:
Psychopharmacology (Berl)
Año:
1991
Tipo del documento:
Article
País de afiliación:
Italia