Rational design of a topical androgen receptor antagonist for the suppression of sebum production with properties suitable for follicular delivery.
J Med Chem
; 53(11): 4422-7, 2010 Jun 10.
Article
en En
| MEDLINE
| ID: mdl-20462217
ABSTRACT
A novel nonsteroidal androgen receptor antagonist, (R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-yloxy)-2-(trifluoromethyl)benzonitrile (1), for the topical control of sebum production is reported. This compound, which is potent, selective, and efficacious in the clinically validated golden Syrian hamster ear animal model, was designed to be delivered to the pilosebaceous unit, the site of action, preferentially by the follicular route.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Sebo
/
Diseño de Fármacos
/
Folículo Piloso
/
Antagonistas de Receptores Androgénicos
/
Nitrilos
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
J Med Chem
Asunto de la revista:
QUIMICA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos