Cutaneous angiosarcoma is a rare aggressive malignant vascular tumour of the skin.
J Eur Acad Dermatol Venereol
; 25(8): 964-8, 2011 Aug.
Article
en En
| MEDLINE
| ID: mdl-21108661
ABSTRACT
BACKGROUND:
Cutaneous angiosarcoma (AS) is a rare aggressive malignant vascular tumour of the skin.METHODS:
We analysed the cases of cutaneous AS in two large dermatological departments of Saxony during the last 10 years.RESULTS:
A total of eight AS cases were identified, mostly with head and neck involvement. Because of age and late diagnosis, only a minor part was completely resectable. As a palliative therapy pegylated liposomal doxorubicin was used. The drug was well tolerated. Our cases and those published in the literature suggest a high rate of responses and a possible sensitisation to subsequent radiation therapy.CONCLUSIONS:
Although complete surgical resection followed by wide-field radiation therapy has been established as a therapeutic standard for AS, delay in diagnosis and older age with comorbidities warrant for a safe and effective adjuvant treatment. Pegylated liposomal doxorubicin combined with radiotherapy seems to be a useful and safe alternative.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Cuidados Paliativos
/
Polietilenglicoles
/
Neoplasias Cutáneas
/
Doxorrubicina
/
Hemangiosarcoma
/
Antibióticos Antineoplásicos
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Límite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Eur Acad Dermatol Venereol
Asunto de la revista:
DERMATOLOGIA
/
DOENCAS SEXUALMENTE TRANSMISSIVEIS
Año:
2011
Tipo del documento:
Article
País de afiliación:
Alemania