Your browser doesn't support javascript.
loading
Response of iron overload to deferasirox in rare transfusion-dependent anaemias: equivalent effects on serum ferritin and labile plasma iron for haemolytic or production anaemias.
Porter, John B; Lin, Kai-Hsin; Beris, Photis; Forni, Gian Luca; Taher, Ali; Habr, Dany; Domokos, Gabor; Roubert, Bernard; Thein, Swee Lay.
Afiliación
  • Porter JB; University College London, London, UK. j.porter@ucl.ac.uk
Eur J Haematol ; 87(4): 338-48, 2011 Oct.
Article en En | MEDLINE | ID: mdl-21649735
ABSTRACT

OBJECTIVES:

It is widely assumed that, at matched transfusional iron-loading rates, responses to chelation therapy are similar, irrespective of the underlying condition. However, data are limited for rare transfusion-dependent anaemias, and it remains to be elucidated if response differs, depending on whether the anaemia has a primary haemolytic or production mechanism.

METHODS:

The efficacy and safety of deferasirox (Exjade®) in rare transfusion-dependent anaemias were evaluated over 1 yr, with change in serum ferritin as the primary efficacy endpoint. Initial deferasirox doses were 10-30 mg/kg/d, depending on transfusion requirements; 34 patients had production anaemias, and 23 had haemolytic anaemias.

RESULTS:

Patients with production anaemias or haemolytic anaemias had comparable transfusional iron-loading rates (0.31 vs. 0.30 mL red blood cells/kg/d), mean deferasirox dosing (19.3 vs. 19.0 mg/kg/d) and baseline median serum ferritin (2926 vs. 2682 ng/mL). Baseline labile plasma iron (LPI) levels correlated significantly with the transfusional iron-loading rates and with serum ferritin levels in both cohorts. Reductions in median serum ferritin levels were initially faster in the production than the haemolytic anaemias, but at 1 yr, similar significant reductions of 940 and 617 ng/mL were attained, respectively (-26.0% overall). Mean LPI decreased significantly in patients with production (P < 0.0001) and haemolytic (P = 0.037) anaemias after the first dose and was maintained at normal mean levels (< 0.4 µm) subsequently. The most common drug-related, investigator-assessed adverse events were diarrhoea (n = 16) and nausea (n = 12).

CONCLUSIONS:

At matched transfusional iron-loading rates, the responses of rare transfusion-dependent anaemias to deferasirox are similar at 1 yr, irrespective of the underlying pathogenic mechanism.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Triazoles / Benzoatos / Transfusión Sanguínea / Quelantes del Hierro / Sobrecarga de Hierro / Ferritinas / Anemia / Hierro Tipo de estudio: Clinical_trials Límite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Eur J Haematol Asunto de la revista: HEMATOLOGIA Año: 2011 Tipo del documento: Article País de afiliación: Reino Unido

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Triazoles / Benzoatos / Transfusión Sanguínea / Quelantes del Hierro / Sobrecarga de Hierro / Ferritinas / Anemia / Hierro Tipo de estudio: Clinical_trials Límite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Eur J Haematol Asunto de la revista: HEMATOLOGIA Año: 2011 Tipo del documento: Article País de afiliación: Reino Unido