Your browser doesn't support javascript.
loading
Cognitive impairment and whole brain diffusion in patients with neuromyelitis optica after acute relapse.
He, Dian; Wu, Qizhu; Chen, Xiuying; Zhao, Daidi; Gong, Qiyong; Zhou, Hongyu.
Afiliación
  • He D; Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Brain Cogn ; 77(1): 80-8, 2011 Oct.
Article en En | MEDLINE | ID: mdl-21723024
The objective of this study investigated cognitive impairments and their correlations with fractional anisotropy (FA) and mean diffusivity (MD) in patients with neuromyelitis optica (NMO) without visible lesions on conventional brain MRI during acute relapse. Twenty one patients with NMO and 21 normal control subjects received several cognitive tests to assess cognitive function. Head diffusion tensor imaging (DTI) of all patients with NMO were collected with a 3-T MR system. Correlations of cognitive test scores and whole brain FA and MD were examined by voxel-based analysis. Region-of-interest analysis was applied to the significantly correlated regions which the most frequently appeared. We found that NMO patients without visible brain lesions had significantly impaired learning and memory, decreased information processing speed, and damaged attention compared with normal control subjects. These impaired cognitive domains were significantly correlated with FA and MD in local regions of corpus callosum, anterior cingulate and medial frontal cortex. In corpus callosum of NMO patients, mean FA was significantly lower and mean MD higher than normal control subjects. Our findings suggest that cognitive impairments in learning and memory, information processing speed and attention occur in NMO patients without visible brain lesions during acute relapse. The impairments in immediate and short-term memory in NMO patients may be due to information encoding deficits in the process of information acquisition. The corpus callosum of such patients may have local microscopic damages that play a role in cognitive impairments during acute relapse.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Encéfalo / Neuromielitis Óptica / Trastornos del Conocimiento / Imagen de Difusión Tensora / Trastornos de la Memoria Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies / Screening_studies Límite: Adult / Humans / Male / Middle aged Idioma: En Revista: Brain Cogn Año: 2011 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Encéfalo / Neuromielitis Óptica / Trastornos del Conocimiento / Imagen de Difusión Tensora / Trastornos de la Memoria Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies / Screening_studies Límite: Adult / Humans / Male / Middle aged Idioma: En Revista: Brain Cogn Año: 2011 Tipo del documento: Article País de afiliación: China