Design and synthesis of novel diphenyl oxalamide and diphenyl acetamide derivatives as anticonvulsants.
Arch Pharm (Weinheim)
; 345(1): 57-64, 2012 Jan.
Article
en En
| MEDLINE
| ID: mdl-21953567
ABSTRACT
A series of novel N(1) -substituted-N(2) ,N(2) -diphenyl oxalamides 3a-l were synthesized in good yield by stirring diphenylcarbamoyl formyl chloride (2) and various substituted aliphatic, alicyclic, aromatic, heterocyclic amines in DMF and K(2) CO(3) . Also 2-substituted amino-N,N-diphenylacetamides 5a-m were designed by pharmacophore generation and synthesized by stirring 2-chloro-N,N-diphenylacetamide (4) and various substituted amines in acetone using triethyl amine as a catalyst. All the synthesized compounds were screened for anticonvulsant activity in Swiss albino mice by MES and ScPTZ induced seizure tests. Neurotoxicity screening and behavioral testing was also carried out. Some of the synthesized test compounds were found to be more potent than the standard drug.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Ácido Oxámico
/
Diseño de Fármacos
/
Ácidos Difenilacéticos
/
Acetamidas
/
Anticonvulsivantes
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
Arch Pharm (Weinheim)
Año:
2012
Tipo del documento:
Article
País de afiliación:
India