Bacterial production of the tunicate-derived antitumor cyclic depsipeptide didemnin B.
J Nat Prod
; 74(11): 2329-31, 2011 Nov 28.
Article
en En
| MEDLINE
| ID: mdl-22035372
Natural products obtained from marine invertebrates such as sponges and tunicates are attractive sources of drugs. However, a critical obstacle in the development of these compounds is the problem of supply. In most cases, neither chemical synthesis nor mariculture of invertebrates is economically feasible. Due to structural similarities, many marine natural products are suspected to be produced by associated microorganisms. A favorable strategy for the production of such compounds is to use culturable microorganisms. Here we report that didemnin B, a tunicate-derived depsipeptide, has been isolated from a culturable bacterium, Tistrella mobilis YIT 12409.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Proteobacteria
/
Depsipéptidos
/
Antineoplásicos
Límite:
Animals
/
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Nat Prod
Año:
2011
Tipo del documento:
Article
País de afiliación:
Japón