Maternal lipids at mid-pregnancy and the risk of preterm delivery.
Acta Obstet Gynecol Scand
; 91(6): 726-35, 2012 Jun.
Article
en En
| MEDLINE
| ID: mdl-22404756
ABSTRACT
OBJECTIVE:
This study examined associations between maternal lipid levels at mid-pregnancy and preterm delivery, medically indicated or spontaneous.DESIGN:
Prospective cohort study.SETTING:
Women were recruited from 52 clinics in five Michigan, USA communities (1998-2004). POPULATION Pregnant women were enrolled at 15-27 weeks' gestation and followed to delivery (n=3019).METHODS:
A single blood sample was obtained at study enrollment. Blood lipids, i.e. total cholesterol (TC), high-density lipoprotein (HDLc), low-density lipoprotein (LDLc) cholesterol, and triglycerides (TG), were measured on a sub-cohort (n=1309). MAIN OUTCOMEMEASURES:
There were 221 spontaneous, 100 medically indicated preterm deliveries and 988 term deliveries. Polytomous logistic regression models examined relationships among cholesterol levels (Low <10(th) percentile, Referent 10(th) -<70(th) percentile, High ≥70(th) percentile), quartiles of TG (Referent first quartile) and delivery outcome (Referent term).RESULTS:
Odds of medically indicated preterm delivery were increased among women with low TC (adjusted odds ratio (aOR)=2.04, 95% confidence interval (CI) 1.12, 3.72), low HDLc (aOR=1.89, 95%CI 1.04, 3.42) or low LDLc (aOR=1.96, 95%CI 1.09, 3.54). Odds of spontaneous preterm delivery were increased among women with high TC (aOR=1.51, 95%CI 1.06, 2.15), high LDLc (aOR=1.42, 95%CI 0.99, 2.04) or high TG (aOR=1.90, 95%CI 1.21, 2.97 and aOR=1.72, 95%CI 1.06, 2.78 for third and fourth quartiles, respectively).CONCLUSIONS:
Extremely low TC, HDLc, and LDLc were associated with a modest increase in risk of medically indicated preterm delivery, whereas high TC, LDLc and TG modestly increased the risk of spontaneous preterm delivery. Further research is needed to uncover explanations for these associations and to identify optimal ranges for maternal lipids.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Segundo Trimestre del Embarazo
/
Nacimiento Prematuro
/
Lípidos
Tipo de estudio:
Clinical_trials
/
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Acta Obstet Gynecol Scand
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos