Iristectorigenin B isolated from Belamcanda chinensis is a liver X receptor modulator that increases ABCA1 and ABCG1 expression in macrophage RAW 264.7 cells.
Biotechnol Lett
; 34(12): 2213-21, 2012 Dec.
Article
en En
| MEDLINE
| ID: mdl-23011313
ABSTRACT
A novel liver X receptor (LXR) modulator, iristectorigenin B isolated from Belamcanda chinensis, stimulated the transcriptional activity of both LXR-α and LXR-ß. In macrophages, iristectorigenin B suppressed cholesterol accumulation in a dose-dependent manner and induced the transcriptional activation of LXR-α/-ß-responsive genes, ATP-binding cassette transporters A1 and G1. It did not induce hepatic lipid accumulation nor the expression of the lipogenesis genes sterol regulatory element-binding protein-1c, fatty acid synthase, and stearoyl-CoA desaturase-1. Iristectorigenin B thus is a dual-LXR agonist that regulates the expression of key genes in cholesterol homeostasis in macrophage cells without inducing hepatic lipid accumulation.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Expresión Génica
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Transportadoras de Casetes de Unión a ATP
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Iridaceae
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Receptores Nucleares Huérfanos
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Isoflavonas
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Lipoproteínas
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Macrófagos
Límite:
Animals
Idioma:
En
Revista:
Biotechnol Lett
Año:
2012
Tipo del documento:
Article
País de afiliación:
Corea del Sur