Who's driving anyway? Herculean efforts to identify the drivers of breast cancer.
Breast Cancer Res
; 14(5): 323, 2012 Oct 31.
Article
en En
| MEDLINE
| ID: mdl-23113888
ABSTRACT
The continuing advancement of sequencing technologies has made the systematic identification of all driving somatic events in cancer a possibility. In the June 2012 issue of Nature, five papers show some significant headway in this endeavor, each a herculean effort of genome sequencing, and transcriptome and copy number analysis resulting in data on thousands of breast cancers. Integrating these massive datasets, the authors were able to further subdivide breast cancer and identify a number of novel driver genes. While the studies represent a leap forward in describing the genomics of breast cancer, and clearly highlight the tremendous diversity between tumors, the studies only scrape the surface of molecular changes in breast tumors, with more granularity to come from the study of epigenomics, single cell sequencing, and so on. The immediate importance of the data to clinical care is currently unknown, and will depend upon detailed identification and functional analysis of driver mutations.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Oncogenes
/
Translocación Genética
/
Neoplasias de la Mama
/
Aromatasa
/
Regulación Neoplásica de la Expresión Génica
/
Genoma Humano
/
Transformación Celular Neoplásica
/
Mutagénesis
/
Evolución Molecular
/
Perfilación de la Expresión Génica
Límite:
Female
/
Humans
Idioma:
En
Revista:
Breast Cancer Res
Asunto de la revista:
NEOPLASIAS
Año:
2012
Tipo del documento:
Article