Novel quinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV.
Bioorg Med Chem Lett
; 23(10): 2955-61, 2013 May 15.
Article
en En
| MEDLINE
| ID: mdl-23566517
A structurally novel set of inhibitors of bacterial type II topoisomerases with potent in vitro and in vivo antibacterial activity was developed. Dual-targeting ability, hERG inhibition, and pharmacokinetic properties were also assessed.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Quinolinas
/
Staphylococcus aureus
/
Streptococcus pneumoniae
/
Topoisomerasa de ADN IV
/
Inhibidores Enzimáticos
/
Inhibidores de Topoisomerasa II
/
Antibacterianos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos