Design of net-charged abc-type collagen heterotrimers.
J Struct Biol
; 185(2): 163-7, 2014 Feb.
Article
en En
| MEDLINE
| ID: mdl-23603270
ABSTRACT
Net-negatively-charged heterospecific ABC collagen peptide heterotrimers were designed using an automated computational approach. The design algorithm considers both target stability and the energy gap between the target states and misfolded competing states. Structural characterization indicates the net-negative charge balance on the new designs enhances the specificity of the target state at the expense of its stability.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Colágeno Tipo III
/
Colágeno Tipo VI
Idioma:
En
Revista:
J Struct Biol
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2014
Tipo del documento:
Article
País de afiliación:
Estados Unidos