Xanthone glycoside constituents of Swertia kouitchensis with α-glucosidase inhibitory activity.
J Nat Prod
; 76(7): 1248-53, 2013 Jul 26.
Article
en En
| MEDLINE
| ID: mdl-23805995
ABSTRACT
Ten new xanthone glycosides, kouitchensides A-J (1-10), and 11 known analogues were isolated from an n-butanol fraction of Swertia kouitchensis. The structures of these glycosides were determined on the basis of extensive spectroscopic data interpretation and comparison with data reported in the literature. In an in vitro test, compounds 2, 4, 5, 6, 11, 12, and 13 (IC50 values in the range 126 to 451 µM) displayed more potent inhibitory effects against α-glucosidase activity than the positive control, acarbose (IC50 value of 627 µM).
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Medicamentos Herbarios Chinos
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Swertia
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Xantonas
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Inhibidores de Glicósido Hidrolasas
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Glicósidos
Idioma:
En
Revista:
J Nat Prod
Año:
2013
Tipo del documento:
Article