Two new chiratane-type triterpenoids from Swertia kouitchensis.

Wan, Luo-Sheng; Liu, Ting-Ting; Lin, Xiao-Jun; Min, Qiu-Xia; Chen, Jia-Chun

Wan, Luo-Sheng; Liu, Ting-Ting; Lin, Xiao-Jun; Min, Qiu-Xia; Chen, Jia-Chun.

Afiliación

Wan LS; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Molecules ; 18(7): 8518-23, 2013 Jul 18.

Article en En | MEDLINE | ID: mdl-23873389

RESUMEN

Two rare new chiratane-type triterpenoids, kouitchenoids A and B (1, 2), together with oleanolic acid (3) and ursolic acid (4), were isolated from ethanol extract of Swertia kouitchensis. The new structures were determined by the analysis of MS and NMR data. In addition, compounds 1-4 showed moderate inhibitory activity against the α-glucosidase (with IC50 values ranging from 1,812 to 2,027 µM).

Asunto(s)

Inhibidores de Glicósido Hidrolasas; Extractos Vegetales/química; Swertia/química; Triterpenos/química; Humanos; Espectroscopía de Resonancia Magnética; Estructura Molecular; Ácido Oleanólico/química; Ácido Oleanólico/aislamiento & purificación; Saccharomyces cerevisiae/enzimología; Triterpenos/aislamiento & purificación; Ácido Ursólico

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Triterpenos / Extractos Vegetales / Swertia / Inhibidores de Glicósido Hidrolasas Límite: Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2013 Tipo del documento: Article País de afiliación: China

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