Gastrointestinal bleeding after high intake of omega-3 fatty acids, cortisone and antibiotic therapy: a case study.
Int J Sport Nutr Exerc Metab
; 24(3): 253-7, 2014 Jun.
Article
en En
| MEDLINE
| ID: mdl-24281788
ABSTRACT
Omega-3 fatty acids exert a plethora of physiological actions including triglycerides lowering, reduction of inflammatory indices, immunomodulation, anti- thrombotic effects and possibly promotion of exercise performance. Their use is widespread and for commonly ingested doses their side- effects are minimal. We report a case of a 60 y amateur athlete who consumed about 20 g omega-3 fatty acids daily from supplements and natural sources for a year. After the intake of cortisone and antibiotics he presented duodenum ulcer and bleeding although he had no previous history of gastrointestinal problems. Although several animal data support gastro-protective effects of omega-3 fatty acids in the present case they were not able to prevent ulcer generation. The present observation may be explained by (i) the high dose of omega-3 fatty acids and their effect on bleeding, (ii) the fact that cortisone increases their oxidation and may render them proinflammatory, (iii) other antithrombotic microconstituents included in the consumed cod-oil and/or the diet of the subject and (iv) the differences in the coagulation and fibrinolytic systems of well- trained subjects. Further studies are needed to substantiate any possible interaction of cortisone and omega-3 fatty acids in wide ranges of intake.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Cortisona
/
Ejercicio Físico
/
Ácidos Grasos Omega-3
/
Suplementos Dietéticos
/
Úlcera Duodenal
/
Hemorragia Gastrointestinal
/
Antibacterianos
Límite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Int J Sport Nutr Exerc Metab
Asunto de la revista:
CIENCIAS DA NUTRICAO
/
MEDICINA ESPORTIVA
/
METABOLISMO
Año:
2014
Tipo del documento:
Article
País de afiliación:
Grecia