Substance P and neurokinins as stimulants of the human isolated urinary bladder.
Neuropeptides
; 11(2): 83-7, 1988.
Article
en En
| MEDLINE
| ID: mdl-2452993
ABSTRACT
Neurokinins are active stimulants of the human isolated urinary bladder. In a preliminary study, performed on bladders taken from four donors, we attempted the characterization of neurokinin receptors. It was shown that neurokinin A is more active than neurokinin B and substance P. Neurokinin receptors selective agonists were also tested and it was found that the most active compound was the NK-A selective agonist, [Nle10]NKA 4-10 A substance P antagonist was able to reduce the effect of neurokinin A but its affinity was rather low. This suggests that the receptor mediating the contraction of the human urinary bladder to neurokinins is of the NK-A (NK2) type. The action of neurokinins on the human urinary bladder appears to be a direct one and mediated by specific receptors different from those of other agents. On the contrary, kinins were found to be active through a new mechanism which was not influenced by either anti-B1 or anti-B2 receptor antagonists.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Vejiga Urinaria
/
Neuropéptidos
/
Sustancia P
Límite:
Adult
/
Humans
/
Middle aged
Idioma:
En
Revista:
Neuropeptides
Año:
1988
Tipo del documento:
Article
País de afiliación:
Canadá