Activation-induced cell death in T lymphocytes from multiple sclerosis patients.
J Neuroimmunol
; 272(1-2): 51-5, 2014 Jul 15.
Article
en En
| MEDLINE
| ID: mdl-24793898
ABSTRACT
Apoptosis is a major mechanism regulating immune tolerance by the elimination of autoreactive T lymphocytes. A failure of activation induced cell-death (AICD) has been described in T lymphocytes from patients with multiple sclerosis (MS). The aims of this study were to evaluate AICD in T lymphocytes from patients with MS and healthy controls, and to explore the molecular mechanisms underlying the deregulation observed in apoptosis induction. PHA-induced AICD was reduced in T lymphocytes from patients with relapsing-remitting MS compared with controls. This finding was associated with a diminished expression of Fas and a failure in caspase 3 activation.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Activación de Linfocitos
/
Linfocitos T
/
Apoptosis
/
Esclerosis Múltiple
Límite:
Adult
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
J Neuroimmunol
Año:
2014
Tipo del documento:
Article
País de afiliación:
España