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Impact of adolescent GluA1 AMPA receptor ablation in forebrain excitatory neurons on behavioural correlates of mood disorders.
Vogt, Miriam A; Elkin, Hasan; Pfeiffer, Natascha; Sprengel, Rolf; Gass, Peter; Inta, Dragos.
Afiliación
  • Vogt MA; Department of Psychiatry and Psychotherapy, RG Animal Models in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Heidelberg, Germany.
Eur Arch Psychiatry Clin Neurosci ; 264(7): 625-9, 2014 Oct.
Article en En | MEDLINE | ID: mdl-24895223
Glutamatergic dysfunctions have recently been postulated to play a considerable role in mood disorders. However, molecular mechanisms underlying these effects have been poorly deciphered. Previous work demonstrated the contribution of GluA1-containing AMPA receptors (AMPAR) to a depression-like and anxiety-like phenotype. Here we investigated the effect of temporally and spatially restricted gene manipulation of GluA1 on behavioural correlates of mood disorders in mice. Here we show that tamoxifen-induced GluA1 deletion restricted to forebrain glutamatergic neurons of post-adolescent mice does not induce depression- and anxiety-like changes. This differs from the phenotype of mice with global AMPAR deletion suggesting that for mood regulation AMPAR may be particularly important on inhibitory interneurons or already early in development.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Regulación de la Expresión Génica / Prosencéfalo / Receptores AMPA / Trastornos del Humor / Desamparo Adquirido / Neuronas Límite: Animals / Female / Humans / Male Idioma: En Revista: Eur Arch Psychiatry Clin Neurosci Asunto de la revista: NEUROLOGIA / PSIQUIATRIA Año: 2014 Tipo del documento: Article País de afiliación: Alemania

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Regulación de la Expresión Génica / Prosencéfalo / Receptores AMPA / Trastornos del Humor / Desamparo Adquirido / Neuronas Límite: Animals / Female / Humans / Male Idioma: En Revista: Eur Arch Psychiatry Clin Neurosci Asunto de la revista: NEUROLOGIA / PSIQUIATRIA Año: 2014 Tipo del documento: Article País de afiliación: Alemania