RNA editing and modifications of RNAs might have favoured the evolution of the triplet genetic code from an ennuplet code.
J Theor Biol
; 359: 1-5, 2014 Oct 21.
Article
en En
| MEDLINE
| ID: mdl-24911781
ABSTRACT
Here we suggest that the origin of the genetic code, that is to say, the birth of first mRNAs has been triggered by means of a widespread modification of all RNAs (proto-mRNAs and proto-tRNAs), as today observed in the RNA editing and in post-transcriptional modifications of RNAs, which are considered as fossils of this evolutionary stage of the genetic code origin. We consider also that other mechanisms, such as the trans-translation and ribosome frameshifting, could have favoured the transition from an ennuplet code to a triplet code. Therefore, according to our hypothesis all these mechanisms would be reflexive of this period of the evolutionary history of the genetic code.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
ARN
/
Procesamiento Postranscripcional del ARN
/
Edición de ARN
/
Evolución Molecular
/
Código Genético
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Theor Biol
Año:
2014
Tipo del documento:
Article