[Expression of novel metastasis-promoting gene 1 and its clinical significance in hepatocellular carcinoma].
Zhonghua Yi Xue Za Zhi
; 94(20): 1530-3, 2014 May 27.
Article
en Zh
| MEDLINE
| ID: mdl-25146738
ABSTRACT
OBJECTIVE:
To explore the expression of NVM-1(novel metastasis-promoting gene 1) in hepatocellular carcinoma (HCC) tissue and examine its clinical significance.METHODS:
The expression of NVM-1 in 92 cases of HCC tumor tissues and non-tumor tissues was detected by immunohistochemical staining with SP (streptavidin-perosidase). And its clinical significance was evaluated.RESULTS:
The staining of NVM-1 was predominantly located in the nucleus of HCC tumor tissue. The positive rate of NVM-1 was 52.2% in all detected cancers and it was higher than that in control non-tumor tissues (28.3%) and benign hepatic lesions (0) . A significant difference of positive rates existed between tumor and non-tumor tissues (P < 0.05). The expression of NVM-1 in HCC was not correlated with hepatic B virus (HBV), size, amount or cirrhosis, etc. However, it was correlated with TNM (P = 0.016), BCLC stage (P = 0.015), poor differentiation (P = 0.000), intrahepatic metastasis (P = 0.002), portal vein tumor thrombus (P = 0.023) and recurrence (P = 0.001). By Kaplan-Meier analysis, the median tumor-free survival time was 5 months in positive expression group and it was significantly shorter than 13 months in negative expression group (P = 0.001).CONCLUSION:
There is probably a close relation between recurrence and metastasis and the expression of NVM-1 in HCC.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Carcinoma Hepatocelular
/
Neoplasias Hepáticas
/
Proteínas de Neoplasias
Límite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Zh
Revista:
Zhonghua Yi Xue Za Zhi
Año:
2014
Tipo del documento:
Article
País de afiliación:
China