Evaluating indirect subthalamic nucleus targeting with validated 3-tesla magnetic resonance imaging.
Stereotact Funct Neurosurg
; 92(6): 337-45, 2014.
Article
en En
| MEDLINE
| ID: mdl-25358805
BACKGROUND/OBJECTIVES: Indirect targeting of the subthalamic nucleus (STN) is commonly utilized at deep brain stimulation (DBS) centers around the world. The superiority of either midcommissural point (MCP)-based or red nucleus (RN)-based indirect targeting remains to be established. METHODS: The location of the STN was determined and statistically compared to MCP- and RN-based predictions in 58 STN DBS patients, using a validated 3-tesla MRI protocol. The influence of additional neuroanatomical parameters on STN midpoint location was evaluated. Linear regression analysis was utilized to produce an optimized MCP/RN targeting model. Targeting coordinates at 1.5 T were compared to results at 3 T. RESULTS: Accuracy and precision for RN-based targeting was superior to MCP-based targeting to predict STN midpoint location for each coordinate dimension (p < 0.01 and p < 0.05, respectively). RN-based targeting was statistically equivalent to an optimized regression-based targeting strategy incorporating multiple neuroanatomical parameters, including third-ventricle width and overall brain size. RN-based targeting at 1.5 T yielded equivalent coordinates to targeting at 3 T. CONCLUSIONS: RN-based targeting is statistically superior to MCP-based STN targeting and accommodates broad variations in neuroanatomical parameters. Neurosurgeons utilizing indirect targeting of the STN may consider favoring RN-based over MCP-based indirect targeting methods.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Núcleo Rojo
/
Imagen por Resonancia Magnética
/
Núcleo Subtalámico
/
Neuronavegación
/
Estimulación Encefálica Profunda
/
Neuroestimuladores Implantables
Tipo de estudio:
Prognostic_studies
Límite:
Aged
/
Humans
/
Middle aged
Idioma:
En
Revista:
Stereotact Funct Neurosurg
Asunto de la revista:
NEUROCIRURGIA
Año:
2014
Tipo del documento:
Article
País de afiliación:
Estados Unidos