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Overexpression of GYS1, MIF, and MYC is associated with adverse outcome and poor response to azacitidine in myelodysplastic syndromes and acute myeloid leukemia.
Falantes, Jose F; Trujillo, Pablo; Piruat, Jose I; Calderón, Cristina; Márquez-Malaver, Francisco J; Martín-Antonio, Beatriz; Millán, Africa; Gómez, Marina; González, Jose; Martino, Maria L; Montero, Isabel; Parody, Rocío; Espigado, Ildefonso; Urbano-Ispizua, Alvaro; Pérez-Simón, Jose A.
Afiliación
  • Falantes JF; Department of Haematology, University Hospital Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS)/CSIC/Universidad de Sevilla, Sevilla, Spain. Electronic address: josef.falantes.sspa@juntadeandalucia.es.
  • Trujillo P; Instituto de Biomedicina de Sevilla (IBIS)/CSIC/Universidad de Sevilla, Sevilla, Spain.
  • Piruat JI; Instituto de Biomedicina de Sevilla (IBIS)/CSIC/Universidad de Sevilla, Sevilla, Spain.
  • Calderón C; Department of Haematology, University Hospital Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS)/CSIC/Universidad de Sevilla, Sevilla, Spain.
  • Márquez-Malaver FJ; Department of Haematology, University Hospital Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS)/CSIC/Universidad de Sevilla, Sevilla, Spain.
  • Martín-Antonio B; Hospital Clinic, IDIBAPS and Institute of Research Josep Carreras, Barcelona, Spain.
  • Millán A; Instituto de Biomedicina de Sevilla (IBIS)/CSIC/Universidad de Sevilla, Sevilla, Spain.
  • Gómez M; Department of Haematology, University Hospital Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS)/CSIC/Universidad de Sevilla, Sevilla, Spain.
  • González J; Department of Haematology, University Hospital Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS)/CSIC/Universidad de Sevilla, Sevilla, Spain.
  • Martino ML; Department of Haematology, University Hospital Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS)/CSIC/Universidad de Sevilla, Sevilla, Spain.
  • Montero I; Department of Haematology, University Hospital Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS)/CSIC/Universidad de Sevilla, Sevilla, Spain.
  • Parody R; Department of Haematology, University Hospital Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS)/CSIC/Universidad de Sevilla, Sevilla, Spain.
  • Espigado I; Department of Haematology, University Hospital Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS)/CSIC/Universidad de Sevilla, Sevilla, Spain.
  • Urbano-Ispizua A; Hospital Clinic, IDIBAPS and Institute of Research Josep Carreras, Barcelona, Spain.
  • Pérez-Simón JA; Department of Haematology, University Hospital Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS)/CSIC/Universidad de Sevilla, Sevilla, Spain.
Clin Lymphoma Myeloma Leuk ; 15(4): 236-44, 2015 Apr.
Article en En | MEDLINE | ID: mdl-25487600
ABSTRACT

BACKGROUND:

The prognosis of myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML) is very heterogeneous. PATIENTS AND

METHODS:

We analyzed the prognostic value of several genes in a cohort of 85 MDS and AML patients.

RESULTS:

Overexpression of glycogen synthase 1 and macrophage migration inhibitory factor genes had an adverse outcome in multivariate analysis (P = .003 and P < .001, respectively). Furthermore, the higher expression of myelocytomatosis oncogene was associated with a lower response to azacitidine (P = .03).

CONCLUSION:

In the current study we identified a specific gene expression profile as prognostic factors for response to azacitidine and survival in MDS and AML.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Síndromes Mielodisplásicos / Leucemia Mieloide Aguda / Expresión Génica / Genes myc / Factores Inhibidores de la Migración de Macrófagos / Glucógeno Sintasa / Oxidorreductasas Intramoleculares Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Humans / Middle aged Idioma: En Revista: Clin Lymphoma Myeloma Leuk Asunto de la revista: NEOPLASIAS Año: 2015 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Síndromes Mielodisplásicos / Leucemia Mieloide Aguda / Expresión Génica / Genes myc / Factores Inhibidores de la Migración de Macrófagos / Glucógeno Sintasa / Oxidorreductasas Intramoleculares Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Humans / Middle aged Idioma: En Revista: Clin Lymphoma Myeloma Leuk Asunto de la revista: NEOPLASIAS Año: 2015 Tipo del documento: Article