Overexpression of GYS1, MIF, and MYC is associated with adverse outcome and poor response to azacitidine in myelodysplastic syndromes and acute myeloid leukemia.
Clin Lymphoma Myeloma Leuk
; 15(4): 236-44, 2015 Apr.
Article
en En
| MEDLINE
| ID: mdl-25487600
ABSTRACT
BACKGROUND:
The prognosis of myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML) is very heterogeneous. PATIENTS ANDMETHODS:
We analyzed the prognostic value of several genes in a cohort of 85 MDS and AML patients.RESULTS:
Overexpression of glycogen synthase 1 and macrophage migration inhibitory factor genes had an adverse outcome in multivariate analysis (P = .003 and P < .001, respectively). Furthermore, the higher expression of myelocytomatosis oncogene was associated with a lower response to azacitidine (P = .03).CONCLUSION:
In the current study we identified a specific gene expression profile as prognostic factors for response to azacitidine and survival in MDS and AML.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Síndromes Mielodisplásicos
/
Leucemia Mieloide Aguda
/
Expresión Génica
/
Genes myc
/
Factores Inhibidores de la Migración de Macrófagos
/
Glucógeno Sintasa
/
Oxidorreductasas Intramoleculares
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
/
Aged80
/
Humans
/
Middle aged
Idioma:
En
Revista:
Clin Lymphoma Myeloma Leuk
Asunto de la revista:
NEOPLASIAS
Año:
2015
Tipo del documento:
Article