Differential expression of the c-erbB-2 gene in human small cell and non-small cell lung cancer.
Cancer Res
; 49(18): 4968-71, 1989 Sep 15.
Article
en En
| MEDLINE
| ID: mdl-2569928
ABSTRACT
We studied non-small cell lung cancers (NSCLC) from 60 patients for abnormalities in the c-erbB-2 gene. Eleven human lung cancer cell lines, including four derived from small cell lung cancer (SCLC) and seven derived from NSCLC were also examined for altered c-erbB-2 gene expression. Southern blot analysis of paired tumor and normal lung samples demonstrated that amplification of the c-erbB-2 gene is rare in NSCLC (2/60) and not restricted to adenocarcinomas. One patient showed an EcoRI restriction fragment length polymorphism for the c-erbB-2 locus. Four of four SCLC cell lines demonstrated minimal or nondetectable expression of c-erbB-2 mRNA compared to high levels of expression by seven of seven NSCLC lines. The highest expression levels were seen in four of four adenocarcinomas. We conclude that c-erbB-2 expression is different in SCLC compared to NSCLC and high expression of c-erbB-2 is consistently present in lung adenocarcinomas.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Proto-Oncogenes
/
Proteínas Proto-Oncogénicas
/
Carcinoma de Células Pequeñas
/
Carcinoma de Pulmón de Células no Pequeñas
/
Neoplasias Pulmonares
Límite:
Humans
Idioma:
En
Revista:
Cancer Res
Año:
1989
Tipo del documento:
Article