Maternal mid-pregnancy lipids and birthweight.
Acta Obstet Gynecol Scand
; 94(8): 852-60, 2015 Aug.
Article
en En
| MEDLINE
| ID: mdl-25912426
ABSTRACT
OBJECTIVE:
To describe associations between maternal lipids and birthweight and to determine whether pre-pregnancy body mass index (BMI) modifies these associations.DESIGN:
Cohort study.SETTING:
Multiple communities in Michigan, USA. POPULATION Participants were a sub-cohort of women from the multi-community Pregnancy Outcomes and Community Health (POUCH) study (1998-2004).METHODS:
Maternal total cholesterol, high-density lipoprotein (HDLc), and low-density lipoprotein (LDLc) cholesterol, and triglycerides were assessed at 16-27 weeks' gestation. Women were classified as having normal (< 25 kg/m(2) ) or overweight/obese (≥ 25 kg/m(2) ) pre-pregnancy BMI. MAIN OUTCOMEMEASURES:
Sex- and gestational-age-specific body weight z-score (BWz).RESULTS:
Regression models examined associations among lipids (low 1st quartile, referent middle quartiles, high 4th quartile) and BWz for the total sample and stratified by pre-pregnancy BMI. In adjusted analyses (n = 1207), low HDLc was associated with lower BWz (ß = -0.23, 95% CI -0.40 to -0.06), whereas high triglycerides were associated with higher BWz (ß = 0.23, 95% CI 0.06-0.41). Once stratified by pre-pregnancy BMI, low total cholesterol was associated with lower BWz in normal BMI women (ß = -0.25, 95% CI -0.47 to -0.03), whereas in overweight/obese BMI women, high HDLc was inversely (ß = -0.29, 95% CI -0.54 to -0.04) and high triglycerides were directly associated with BWz (ß = 0.32, 95% CI 0.07-0.54). Removing women with gestational diabetes/hypertensive disorders did not alter the results.CONCLUSIONS:
The associations between maternal lipids and BWz vary by lipid measure and pre-pregnancy BMI. Future work should examine whether lipids and pre-pregnancy BMI make unique contributions to the fetal programming of disease.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Complicaciones del Embarazo
/
Triglicéridos
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Peso al Nacer
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Colesterol
/
Lípidos
/
Obesidad
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Male
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Newborn
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Pregnancy
Idioma:
En
Revista:
Acta Obstet Gynecol Scand
Año:
2015
Tipo del documento:
Article
País de afiliación:
Estados Unidos