[Associations of SUMO4 polymorphisms with tacrolimus concentrations in Chinese renal transplant recipients].
Yao Xue Xue Bao
; 50(2): 180-4, 2015 Feb.
Article
en Zh
| MEDLINE
| ID: mdl-25975025
ABSTRACT
The study aims to investigate the associations of SUMO4 polymorphisms with tacrolimus concentrations in Chinese renal transplant recipients. Blood samples and clinical data were collected from 132 renal transplant recipients with tacrolimus treatment. CYP3A5*3 genotypes were detected by PCR-RFLP, and SUMO4 (rs237024, rs237025) genotypes were detected by Sequenom® MassARRAY system. SUMO4 rs237024 and rs237025 genotypes were in complete linkage disequilibrium (D' = 1). The dose-adjusted concentration of tacrolimus in SUMO4 rs237024A-rs237025A (GA-GA +AA-AA) carriers was considerably higher than that in GG-GG carriers (P < 0.05). After stratification by CYP3A5*3 genotypes, SUMO4 rs237024A-rs237025A carriers (GA-GA+AA-AA) had a higher dose-adjusted tacrolimus concentration than that in GG carriers in CYP3A5 expresser (P < 0.05). The results illustrated that SUMO4 rs237024 and rs237025 polymorphisms were associated with tacrolimus concentrations, and the test of these genotypes may be useful for individualized medicine of tacrolimus.
Buscar en Google
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Trasplante de Riñón
/
Tacrolimus
/
Polimorfismo de Nucleótido Simple
/
Proteínas Modificadoras Pequeñas Relacionadas con Ubiquitina
/
Inmunosupresores
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
Zh
Revista:
Yao Xue Xue Bao
Año:
2015
Tipo del documento:
Article