Longitudinal epigenetic and gene expression profiles analyzed by three-component analysis reveal down-regulation of genes involved in protein translation in human aging.

Jung, Marc; Jin, Seung-Gi; Zhang, Xiaoying; Xiong, Wenying; Gogoshin, Grigoriy; Rodin, Andrei S; Pfeifer, Gerd P

Jung, Marc; Jin, Seung-Gi; Zhang, Xiaoying; Xiong, Wenying; Gogoshin, Grigoriy; Rodin, Andrei S; Pfeifer, Gerd P.

Afiliación

Jung M; Department of Cancer Biology, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA mjung@illumina.com.
Jin SG; Department of Cancer Biology, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA.
Zhang X; Department of Cancer Biology, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA.
Xiong W; Department of Cancer Biology, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA.
Gogoshin G; Center for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA.
Rodin AS; Center for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA arodin@coh.org.
Pfeifer GP; Department of Cancer Biology, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA gerd.pfeifer@vai.org.

Nucleic Acids Res ; 43(15): e100, 2015 Sep 03.

Article en En | MEDLINE | ID: mdl-25977295

Asunto(s)

Envejecimiento/genética; Epigénesis Genética; Perfilación de la Expresión Génica; Biosíntesis de Proteínas; Adulto; Anciano; Algoritmos; Células Cultivadas; Análisis por Conglomerados; Metilación de ADN; Regulación hacia Abajo; Factores de Transcripción Forkhead/metabolismo; Histonas/metabolismo; Humanos; Masculino; Metilación; Persona de Mediana Edad; Piel/metabolismo; Estadísticas no Paramétricas

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Biosíntesis de Proteínas / Envejecimiento / Perfilación de la Expresión Génica / Epigénesis Genética Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies Límite: Adult / Aged / Humans / Male / Middle aged Idioma: En Revista: Nucleic Acids Res Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos

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