Tobacco smoking and tuberculosis treatment outcomes: a prospective cohort study in Georgia.
Bull World Health Organ
; 93(6): 390-9, 2015 Jun 01.
Article
en En
| MEDLINE
| ID: mdl-26240460
ABSTRACT
OBJECTIVE:
To assess the effect of tobacco smoking on the outcome of tuberculosis treatment in Tbilisi, Georgia.METHODS:
We conducted a prospective cohort study of adults with laboratory-confirmed tuberculosis from May 2011 to November 2013. History of tobacco smoking was collected using a standardized questionnaire adapted from the global adult tobacco survey. We considered tuberculosis therapy to have a poor outcome if participants defaulted, failed treatment or died. We used multivariable regressions to estimate the risk of a poor treatment outcome.FINDINGS:
Of the 591 tuberculosis patients enrolled, 188 (31.8%) were past smokers and 271 (45.9%) were current smokers. Ninety (33.2%) of the current smokers and 24 (18.2%) of the participants who had never smoked had previously been treated for tuberculosis (P < 0.01). Treatment outcome data were available for 524 of the participants, of whom 128 (24.4%) - including 80 (32.9%) of the 243 current smokers and 21 (17.2%) of the 122 individuals who had never smoked - had a poor treatment outcome. Compared with those who had never smoked, current smokers had an increased risk of poor treatment outcome (adjusted relative risk, aRR 1.70; 95% confidence interval, CI 1.00-2.90). Those who had ceased smoking more than two months before enrolment did not have such an increased risk (aRR 1.01; 95% CI 0.51-1.99).CONCLUSION:
There is a high prevalence of smoking among patients with tuberculosis in Georgia and smoking increases the risk of a poor treatment outcome.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Tuberculosis
/
Fumar
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Límite:
Adolescent
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Adult
/
Female
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Humans
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Male
/
Middle aged
País/Región como asunto:
Europa
Idioma:
En
Revista:
Bull World Health Organ
Año:
2015
Tipo del documento:
Article
País de afiliación:
Georgia