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Dinuclear Gold(I) Pyrrolidinedithiocarbamato Complex: Cytotoxic and Antimigratory Activities on Cancer Cells and the Use of Metal-Organic Framework.
Sun, Raymond Wai-Yin; Zhang, Ming; Li, Dan; Zhang, Zhi-Feng; Cai, Hong; Li, Mian; Xian, Yue-Jiao; Ng, Seik Weng; Wong, Alice Sze-Tsai.
Afiliación
  • Sun RW; Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, 243 Da Xue Road, Shantou, Guangdong 515063 (P. R. China). rwysun@stu.edu.cn.
  • Zhang M; Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, 243 Da Xue Road, Shantou, Guangdong 515063 (P. R. China).
  • Li D; Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, 243 Da Xue Road, Shantou, Guangdong 515063 (P. R. China). dli@stu.edu.cn.
  • Zhang ZF; Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, 243 Da Xue Road, Shantou, Guangdong 515063 (P. R. China).
  • Cai H; Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, 243 Da Xue Road, Shantou, Guangdong 515063 (P. R. China).
  • Li M; Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, 243 Da Xue Road, Shantou, Guangdong 515063 (P. R. China).
  • Xian YJ; Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, 243 Da Xue Road, Shantou, Guangdong 515063 (P. R. China).
  • Ng SW; Department of Chemistry, University of Malaya, 50603 Kuala Lumpur (Malaysia).
  • Wong AS; Chemistry Department, King Abdulaziz University, 80203 Jeddah (Saudi Arabia).
Chemistry ; 21(51): 18534-8, 2015 Dec 14.
Article en En | MEDLINE | ID: mdl-26459298
ABSTRACT
A dinuclear gold(I) pyrrolidinedithiocarbamato complex (1) with a bidentate carbene ligand has been constructed and shows potent in vitro cytotoxic activities towards cisplatin-resistant ovarian cancer cells A2780cis. Its rigid scaffold enables a zinc(II)-based metal-organic framework (Zn-MOF) to be used as a carrier in facilitating the uptake and release of 1 in solutions. Instead of using a conventional dialysis approach for the drug-release testing, in this study, a set of transwell assay-based experiments have been designed and employed to examine the cytotoxic and antimigratory activities of 1@Zn-MOF towards A2780cis.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Tiocarbamatos / Zinc / Cisplatino / Compuestos de Oro / Oro Límite: Female / Humans Idioma: En Revista: Chemistry Asunto de la revista: QUIMICA Año: 2015 Tipo del documento: Article
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Tiocarbamatos / Zinc / Cisplatino / Compuestos de Oro / Oro Límite: Female / Humans Idioma: En Revista: Chemistry Asunto de la revista: QUIMICA Año: 2015 Tipo del documento: Article