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Accelerated Unilateral Radiographic Huntingtonian Changes Following Neoadjuvant Chemotherapy for a Nongerminomatous Germ Cell Tumor Leading to Identification of Occult Disease in the Dorsal Striatum.
Lucas, John T; Zapadka, Michael; Houseknecht, Kristin; Buckley, Kevin S; Couture, Daniel E; Brown, Doris R.
Afiliación
  • Lucas JT; *Department of Radiation Oncology, St Jude Children's Research Hospital, Memphis, TN ‡Department of Radiation Oncology §Department of Pediatrics, Division of Pediatric Hematology Oncology †Department of Radiology, Division of Neuroradiology ∥Department of Neurosurgery, Wake Forest Baptist Medical Center, Childress Institute of Pediatrics, Winston Salem, NC.
J Pediatr Hematol Oncol ; 38(2): 161-2, 2016 Mar.
Article en En | MEDLINE | ID: mdl-26479984
Basal ganglia nongerminomatous germ cell tumors comprise 10% to 15% of germ cell tumor and have substantial morbidity at the time of local failure. In this submitted image we present a case where neoadjuvant chemotherapy unmasked a unilateral caudate head loss consistent with Huntingtonian changes. Careful review of the patient's imaging identified disease within the dorsal striatum that was not previously identified at the time of diagnosis. Review of the diffusion tensor fractional anisotropy imaging identified progressive white matter likely secondary to the occult disease within the dorsal striatum. Although this patient was asymptomatic and had no signs of a movement disorder, similar findings have been noted to be a prelude to such findings several months later. The occult disease was incorporated into the patient's radiotherapy planning target volume as oversight of these changes would have led to a marginal miss and potential early disease relapse.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Enfermedad de Huntington / Neoplasias de Células Germinales y Embrionarias Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Child / Humans / Male Idioma: En Revista: J Pediatr Hematol Oncol Asunto de la revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Año: 2016 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Enfermedad de Huntington / Neoplasias de Células Germinales y Embrionarias Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Child / Humans / Male Idioma: En Revista: J Pediatr Hematol Oncol Asunto de la revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Año: 2016 Tipo del documento: Article