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Higher incidence of the SNP Met 788 Ile in the coding region of A20 in diffuse large B cell lymphomas.
Wenzl, Kerstin; Hofer, Sybille; Troppan, Katharina; Lassnig, Markus; Steinbauer, Elisabeth; Wiltgen, Marco; Zulus, Barbara; Renner, Wilfried; Beham-Schmid, Christine; Neumeister, Peter; Deutsch, Alexander.
Afiliación
  • Wenzl K; Division of Hematology, Department of Internal Medicine, Medical University of Graz Austria, Graz, Austria.
  • Hofer S; Division of Hematology, Department of Internal Medicine, Medical University of Graz Austria, Graz, Austria.
  • Troppan K; Division of Hematology, Department of Internal Medicine, Medical University of Graz Austria, Graz, Austria.
  • Lassnig M; Division of Hematology, Department of Internal Medicine, Medical University of Graz Austria, Graz, Austria.
  • Steinbauer E; Institute of Pathology, Medical University of Graz Austria, Graz, Austria.
  • Wiltgen M; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz Austria, Graz, Austria.
  • Zulus B; Division of Medical and Chemical Laboratory Diagnostics, Medical University of Graz Austria, Graz, Austria.
  • Renner W; Division of Medical and Chemical Laboratory Diagnostics, Medical University of Graz Austria, Graz, Austria.
  • Beham-Schmid C; Institute of Pathology, Medical University of Graz Austria, Graz, Austria.
  • Neumeister P; Division of Hematology, Department of Internal Medicine, Medical University of Graz Austria, Graz, Austria.
  • Deutsch A; Division of Hematology, Department of Internal Medicine, Medical University of Graz Austria, Graz, Austria. alexander.deutsch@medunigraz.at.
Tumour Biol ; 37(4): 4785-9, 2016 Apr.
Article en En | MEDLINE | ID: mdl-26518771
ABSTRACT
Genetic alterations causing constitutive activation of the nuclear factor kappa B (NF-κB) signaling pathway has been associated with the development of lymphomas. A20 (TNFAIP3) is a key regulator of NF-κB signaling. Its suppressor functions are often inactivated by deletions and/or mutations in various hematologic malignancies. Since we recently found the rs143002189 polymorphism in the A20 loci in our multiple myeloma samples, we further investigated this polymorphism in different lymphoid neoplasias. For this purpose, we tested 479 cases of the most common B cell malignancies for the presence of the rs143002189 polymorphism. We found a significant higher occurrence of the rs143002189 polymorphism in diffuse large B cell lymphoma (DLBCL) compared to non-neoplastic controls and other types of B cell malignancies. Furthermore, structure analyses of the mutated A20 protein led to the assumption that the new steric interaction within the protein is responsible for a reduced or inactivated A20 protein. Our data indicates that in a significant fraction of patients, rs143002189 might contribute to the development of DLBCL.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Linfoma de Células B Grandes Difuso / Polimorfismo de Nucleótido Simple / Proteína 3 Inducida por el Factor de Necrosis Tumoral alfa Tipo de estudio: Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Tumour Biol Asunto de la revista: NEOPLASIAS Año: 2016 Tipo del documento: Article País de afiliación: Austria

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Linfoma de Células B Grandes Difuso / Polimorfismo de Nucleótido Simple / Proteína 3 Inducida por el Factor de Necrosis Tumoral alfa Tipo de estudio: Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Tumour Biol Asunto de la revista: NEOPLASIAS Año: 2016 Tipo del documento: Article País de afiliación: Austria