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Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance.
Vukovic, Milica; Guitart, Amelie V; Sepulveda, Catarina; Villacreces, Arnaud; O'Duibhir, Eoghan; Panagopoulou, Theano I; Ivens, Alasdair; Menendez-Gonzalez, Juan; Iglesias, Juan Manuel; Allen, Lewis; Glykofrydis, Fokion; Subramani, Chithra; Armesilla-Diaz, Alejandro; Post, Annemarie E M; Schaak, Katrin; Gezer, Deniz; So, Chi Wai Eric; Holyoake, Tessa L; Wood, Andrew; O'Carroll, Dónal; Ratcliffe, Peter J; Kranc, Kamil R.
Afiliación
  • Vukovic M; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, Scotland, UK.
  • Guitart AV; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, Scotland, UK.
  • Sepulveda C; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, Scotland, UK.
  • Villacreces A; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, Scotland, UK.
  • O'Duibhir E; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, Scotland, UK.
  • Panagopoulou TI; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, Scotland, UK.
  • Ivens A; Centre for Infection, Immunity, and Evolution, King's Buildings, University of Edinburgh, Edinburgh EH9 3FL, Scotland, UK.
  • Menendez-Gonzalez J; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, Scotland, UK.
  • Iglesias JM; Synpromics Limited, Edinburgh EH16 4UX, Scotland, UK.
  • Allen L; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, Scotland, UK.
  • Glykofrydis F; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, Scotland, UK.
  • Subramani C; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, Scotland, UK.
  • Armesilla-Diaz A; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, Scotland, UK.
  • Post AE; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, Scotland, UK.
  • Schaak K; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, Scotland, UK.
  • Gezer D; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, Scotland, UK Klinik fuer Haematologie, Onkologie und Stammzelltransplantation, Universitaetsklinikum Aachen, 52074 Aachen, Germany Paul O'Gorman Leukaemia Research Centre, University of Glasgow, Glasgow G120 ZD, Scotl
  • So CW; Department of Haematological Medicine, King's College London, London SE5 9RS, England, UK.
  • Holyoake TL; Paul O'Gorman Leukaemia Research Centre, University of Glasgow, Glasgow G120 ZD, Scotland, UK.
  • Wood A; Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, Scotland, UK.
  • O'Carroll D; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, Scotland, UK European Molecular Biology Laboratory (EMBL), Mouse Biology Unit, 00015 Monterotondo Scalo, Italy.
  • Ratcliffe PJ; Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7BN, England, UK.
  • Kranc KR; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, Scotland, UK Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, Scotland, UK kamil.kranc@ed.ac.uk.
J Exp Med ; 212(13): 2223-34, 2015 Dec 14.
Article en En | MEDLINE | ID: mdl-26642852
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / Progresión de la Enfermedad / Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico / Subunidad alfa del Factor 1 Inducible por Hipoxia Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Exp Med Año: 2015 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / Progresión de la Enfermedad / Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico / Subunidad alfa del Factor 1 Inducible por Hipoxia Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Exp Med Año: 2015 Tipo del documento: Article País de afiliación: Reino Unido