[Sézary syndrome treated with extracorporeal photopheresis: Report of one case]. / Fotoféresis en el tratamiento de Síndrome de Sézary: Caso clínico.
Rev Med Chil
; 143(11): 1449-58, 2015 Nov.
Article
en Es
| MEDLINE
| ID: mdl-26757870
ABSTRACT
Sézary syndrome (SS) is an unusually aggressive T- cell lymphoma characterized by the triad of erythroderma, the presence of more than 1,000 Sézary cells in peripheral blood and lymphadenopathies. It is accompanied by generalized pruritus and poor quality of life. The management of SS depends on its stage, patient comorbidities, and treatment availability. Extracorporeal photopheresis (ECP) is the first line of treatment for patients with T-cell lymphomas in stage IVA1, IVA2 or SS. This treatment comprises three phases leukapheresis, photoactivation and subsequent reinfusion of lymphocytes. As it is an immunomodulatory therapy it does not produce generalized immunosuppression. We report a 76 year-old male with SS stage IIIb initially treated with 12 sessions of ultraviolet phototherapy without response. After 10 well-tolerated sessions of ECP, itching and skin lesions eventually disappeared.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Cutáneas
/
Síndrome de Sézary
/
Fotoféresis
Límite:
Aged
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Humans
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Male
Idioma:
Es
Revista:
Rev Med Chil
Año:
2015
Tipo del documento:
Article