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GWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer.
Chen, Maxine M; O'Mara, Tracy A; Thompson, Deborah J; Painter, Jodie N; Attia, John; Black, Amanda; Brinton, Louise; Chanock, Stephen; Chen, Chu; Cheng, Timothy Ht; Cook, Linda S; Crous-Bou, Marta; Doherty, Jennifer; Friedenreich, Christine M; Garcia-Closas, Montserrat; Gaudet, Mia M; Gorman, Maggie; Haiman, Christopher; Hankinson, Susan E; Hartge, Patricia; Henderson, Brian E; Hodgson, Shirley; Holliday, Elizabeth G; Horn-Ross, Pamela L; Hunter, David J; Le Marchand, Loic; Liang, Xiaolin; Lissowska, Jolanta; Long, Jirong; Lu, Lingeng; Magliocco, Anthony M; Martin, Lynn; McEvoy, Mark; Olson, Sara H; Orlow, Irene; Pooler, Loreall; Prescott, Jennifer; Rastogi, Radhai; Rebbeck, Timothy R; Risch, Harvey; Sacerdote, Carlotta; Schumacher, Frederick; Wendy Setiawan, Veronica; Scott, Rodney J; Sheng, Xin; Shu, Xiao-Ou; Turman, Constance; Van Den Berg, David; Wang, Zhaoming; Weiss, Noel S.
Afiliación
  • Chen MM; Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA 02115, USA.
  • O'Mara TA; Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Herston, Brisbane, QLD 4006, Australia.
  • Thompson DJ; Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.
  • Painter JN; Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Herston, Brisbane, QLD 4006, Australia.
  • Attia J; Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW 2305, Australia.
  • Black A; School of Medicine and Public Health, Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, NSW 2308, Australia.
  • Brinton L; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
  • Chanock S; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
  • Chen C; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
  • Cheng TH; Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
  • Cook LS; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
  • Crous-Bou M; University of New Mexico, Albuquerque, NM 87131, USA.
  • Doherty J; Division of Cancer Care, Department of Population Health Research, Alberta Health Services, Calgary, AB, Canada.
  • Friedenreich CM; Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA 02115, USA.
  • Garcia-Closas M; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Gaudet MM; Geisel School of Medicine, Dartmouth College, Lebanon, NH 03755, USA.
  • Gorman M; Department of Cancer Epidemiology and Prevention Research, Cancer Control Alberta, Alberta Health Services, Calgary, AB, Canada.
  • Haiman C; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
  • Hankinson SE; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
  • Hartge P; Epidemiology Research Program, American Cancer Society, Atlanta, GA 30329, USA.
  • Henderson BE; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
  • Hodgson S; University of Southern California, Los Angeles, CA 90033, USA.
  • Holliday EG; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Horn-Ross PL; Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst MA 01003, USA.
  • Hunter DJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
  • Le Marchand L; University of Southern California, Los Angeles, CA 90033, USA.
  • Liang X; Department of Clinical Genetics, St George's, University of London, London SW17 0RE, UK.
  • Lissowska J; Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW 2305, Australia.
  • Long J; Cancer Prevention Institute of California, Fremont, CA 94538, USA.
  • Lu L; Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA 02115, USA.
  • Magliocco AM; University of Hawaii Cancer Center, Honolulu, HI 96813, USA.
  • Martin L; Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • McEvoy M; Department of Cancer Epidemiology and Prevention, M Sklodowska-Curie Cancer Center and Institute of Oncology, Warsaw, Poland.
  • Olson SH; Yale University School of Public Health, New Haven, CT 06510, USA.
  • Orlow I; H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
  • Pooler L; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
  • Prescott J; School of Medicine and Public Health, Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, NSW 2308, Australia.
  • Rebbeck TR; Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Risch H; Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Sacerdote C; University of Southern California, Los Angeles, CA 90033, USA.
  • Schumacher F; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Wendy Setiawan V; Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Scott RJ; Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  • Sheng X; Yale University School of Public Health, New Haven, CT 06510, USA.
  • Shu XO; Center for Cancer Prevention (CPO-Piemonte), Turin, Italy.
  • Turman C; Human Genetic Foundation (HuGeF), Turin, Italy.
  • Van Den Berg D; University of Southern California, Los Angeles, CA 90033, USA.
  • Wang Z; University of Southern California, Los Angeles, CA 90033, USA.
  • Weiss NS; Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW 2305, Australia.
Hum Mol Genet ; 25(12): 2612-2620, 2016 06 15.
Article en En | MEDLINE | ID: mdl-27008869
ABSTRACT
Endometrial cancer is the most common gynecological malignancy in the developed world. Although there is evidence of genetic predisposition to the disease, most of the genetic risk remains unexplained. We present the meta-analysis results of four genome-wide association studies (4907 cases and 11 945 controls total) in women of European ancestry. We describe one new locus reaching genome-wide significance (P < 5 × 10 -8) at 6p22.3 (rs1740828; P = 2.29 × 10 -8, OR = 1.20), providing evidence of an additional region of interest for genetic susceptibility to endometrial cancer.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Endometriales / Predisposición Genética a la Enfermedad / Estudio de Asociación del Genoma Completo Tipo de estudio: Systematic_reviews Límite: Female / Humans Idioma: En Revista: Hum Mol Genet Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
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Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Endometriales / Predisposición Genética a la Enfermedad / Estudio de Asociación del Genoma Completo Tipo de estudio: Systematic_reviews Límite: Female / Humans Idioma: En Revista: Hum Mol Genet Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos