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Lewis Acid Catalyzed Friedel-Crafts Alkylation of Alkenes with Trifluoropyruvates.
Xiang, Bin; Xu, Teng-Fei; Wu, Liang; Liu, Ren-Rong; Gao, Jian-Rong; Jia, Yi-Xia.
Afiliación
  • Xiang B; College of Chemical Engineering, Zhejiang University of Technology , Hangzhou 310014, China.
  • Xu TF; College of Chemical Engineering, Zhejiang University of Technology , Hangzhou 310014, China.
  • Wu L; College of Chemical Engineering, Zhejiang University of Technology , Hangzhou 310014, China.
  • Liu RR; College of Chemical Engineering, Zhejiang University of Technology , Hangzhou 310014, China.
  • Gao JR; College of Chemical Engineering, Zhejiang University of Technology , Hangzhou 310014, China.
  • Jia YX; College of Chemical Engineering, Zhejiang University of Technology , Hangzhou 310014, China.
J Org Chem ; 81(9): 3929-35, 2016 05 06.
Article en En | MEDLINE | ID: mdl-27028539
ABSTRACT
A Friedel-Crafts alkylation reaction of styrenes with trifluoropyruvates has been developed, which delivered allylic alcohols in excellent yields (up to 98%) using the Ni(ClO4)2·6H2O/bipyridine complex as a catalyst. The asymmetric reaction was catalyzed by the chiral Cu(OTf)2/bisoxazoline complex to afford the corresponding chiral allylic alcohols bearing trifluoromethylated quaternary stereogenic centers in moderate enantioselectivities (up to 75% ee).
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: J Org Chem Año: 2016 Tipo del documento: Article País de afiliación: China
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: J Org Chem Año: 2016 Tipo del documento: Article País de afiliación: China