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Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels.
van Leeuwen, Elisabeth M; Sabo, Aniko; Bis, Joshua C; Huffman, Jennifer E; Manichaikul, Ani; Smith, Albert V; Feitosa, Mary F; Demissie, Serkalem; Joshi, Peter K; Duan, Qing; Marten, Jonathan; van Klinken, Jan B; Surakka, Ida; Nolte, Ilja M; Zhang, Weihua; Mbarek, Hamdi; Li-Gao, Ruifang; Trompet, Stella; Verweij, Niek; Evangelou, Evangelos; Lyytikäinen, Leo-Pekka; Tayo, Bamidele O; Deelen, Joris; van der Most, Peter J; van der Laan, Sander W; Arking, Dan E; Morrison, Alanna; Dehghan, Abbas; Franco, Oscar H; Hofman, Albert; Rivadeneira, Fernando; Sijbrands, Eric J; Uitterlinden, Andre G; Mychaleckyj, Josyf C; Campbell, Archie; Hocking, Lynne J; Padmanabhan, Sandosh; Brody, Jennifer A; Rice, Kenneth M; White, Charles C; Harris, Tamara; Isaacs, Aaron; Campbell, Harry; Lange, Leslie A; Rudan, Igor; Kolcic, Ivana; Navarro, Pau; Zemunik, Tatijana; Salomaa, Veikko; Kooner, Angad S.
Afiliación
  • van Leeuwen EM; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
  • Sabo A; Human Genome Sequencing Center, Baylor College of Medicine, Houston, USA.
  • Bis JC; Department of Medicine, University of Washington, Seattle, USA.
  • Huffman JE; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK The Framingham Heart Study, NHLBI Cardiovascular Epidemiology and Human Genomics Branch, Framingham, USA.
  • Manichaikul A; Center for Public Health Genomics, University of Virginia, Charlottesville, USA.
  • Smith AV; Icelandic Heart Association, Kopavogur, Iceland Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
  • Feitosa MF; Department of Genetics, Washington University School of Medicine, St Louis, USA.
  • Demissie S; Department of Biostatistics, Boston University School of Public Health, Boston, USA.
  • Joshi PK; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
  • Duan Q; Department of Genetics, University of North Carolina, Chapel Hill, USA.
  • Marten J; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
  • van Klinken JB; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
  • Surakka I; Human Genomics Unit, Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland.
  • Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Zhang W; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK Department of Cardiology, Ealing Hospital NHS Trust, Middlesex, UK.
  • Mbarek H; Department of Biological Psychology, VU University Amsterdam and EMGO+ Institute for Health and Care Research, Amsterdam, The Netherlands.
  • Li-Gao R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
  • Trompet S; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
  • Verweij N; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Evangelou E; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
  • Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, Finland.
  • Tayo BO; Public Health Sciences, Loyola University Chicago Stritch School of Medicine, Maywood, USA.
  • Deelen J; Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
  • van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • van der Laan SW; Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Arking DE; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, USA.
  • Morrison A; Human Genetics Center, The University of Texas School of Public Health, Houston, USA.
  • Dehghan A; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
  • Franco OH; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
  • Hofman A; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
  • Rivadeneira F; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
  • Sijbrands EJ; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
  • Uitterlinden AG; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
  • Mychaleckyj JC; Center for Public Health Genomics, University of Virginia, Charlottesville, USA.
  • Campbell A; Generation Scotland, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
  • Hocking LJ; Musculoskeletal Research Programme, Division of Applied Medicine, University of Aberdeen, Aberdeen, UK.
  • Padmanabhan S; British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
  • Brody JA; Department of Medicine, University of Washington, Seattle, USA.
  • Rice KM; Department of Biostatistics, University of Washington, Seattle, USA.
  • White CC; Brigham and Women's Hospital, Boston, USA.
  • Harris T; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, USA.
  • Isaacs A; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
  • Campbell H; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
  • Lange LA; Department of Genetics, University of North Carolina, Chapel Hill, USA.
  • Rudan I; Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.
  • Kolcic I; Faculty of Medicine, University of Split, Split, Croatia.
  • Navarro P; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
  • Zemunik T; Faculty of Medicine, University of Split, Split, Croatia.
  • Salomaa V; Department of Health, National Institute for Health and Welfare, Helsinki, Finland.
  • Kooner AS; Cardiovascular Science, National Heart and Lung Institute, Imperial College London, London, UK.
J Med Genet ; 53(7): 441-9, 2016 07.
Article en En | MEDLINE | ID: mdl-27036123
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Genoma Humano / Exones / Polimorfismo de Nucleótido Simple / Angiopoyetinas Tipo de estudio: Systematic_reviews Límite: Female / Humans / Male / Middle aged Idioma: En Revista: J Med Genet Año: 2016 Tipo del documento: Article País de afiliación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Genoma Humano / Exones / Polimorfismo de Nucleótido Simple / Angiopoyetinas Tipo de estudio: Systematic_reviews Límite: Female / Humans / Male / Middle aged Idioma: En Revista: J Med Genet Año: 2016 Tipo del documento: Article País de afiliación: Países Bajos