Cellular Homeostasis and Aging.
Annu Rev Biochem
; 85: 1-4, 2016 Jun 02.
Article
en En
| MEDLINE
| ID: mdl-27050288
ABSTRACT
Aging and longevity are controlled by a multiplicity of molecular and cellular signaling events that interface with environmental factors to maintain cellular homeostasis. Modulation of these pathways to extend life span, including insulin-like signaling and the response to dietary restriction, identified the cellular machineries and networks of protein homeostasis (proteostasis) and stress resistance pathways as critical players in the aging process. A decline of proteostasis capacity during aging leads to dysfunction of specific cell types and tissues, rendering the organism susceptible to a range of chronic diseases. This volume of the Annual Review of Biochemistry contains a set of two reviews addressing our current understanding of the molecular mechanisms underlying aging in model organisms and humans.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Envejecimiento
/
Factor 2 Eucariótico de Iniciación
/
Proteínas Serina-Treonina Quinasas
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Caenorhabditis elegans
/
Regulación del Desarrollo de la Expresión Génica
/
Respuesta de Proteína Desplegada
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Annu Rev Biochem
Año:
2016
Tipo del documento:
Article