Recent discoveries of influenza A drug target sites to combat virus replication.
Biochem Soc Trans
; 44(3): 932-6, 2016 06 15.
Article
en En
| MEDLINE
| ID: mdl-27284062
ABSTRACT
Sequence variations in the binding sites of influenza A proteins are known to limit the effectiveness of current antiviral drugs. Clinically, this leads to increased rates of virus transmission and pathogenicity. Potential influenza A inhibitors are continually being discovered as a result of high-throughput cell based screening studies, whereas the application of computational tools to aid drug discovery has further increased the number of predicted inhibitors reported. This review brings together the aspects that relate to the identification of influenza A drug target sites and the findings from recent antiviral drug discovery strategies.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Antivirales
/
Virus de la Influenza A
/
Replicación Viral
/
Gripe Humana
/
Descubrimiento de Drogas
/
Terapia Molecular Dirigida
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Biochem Soc Trans
Año:
2016
Tipo del documento:
Article
País de afiliación:
Reino Unido