Validating silicon polytrodes with paired juxtacellular recordings: method and dataset.
J Neurophysiol
; 116(2): 892-903, 2016 08 01.
Article
en En
| MEDLINE
| ID: mdl-27306671
ABSTRACT
Cross-validating new methods for recording neural activity is necessary to accurately interpret and compare the signals they measure. Here we describe a procedure for precisely aligning two probes for in vivo "paired-recordings" such that the spiking activity of a single neuron is monitored with both a dense extracellular silicon polytrode and a juxtacellular micropipette. Our new method allows for efficient, reliable, and automated guidance of both probes to the same neural structure with micrometer resolution. We also describe a new dataset of paired-recordings, which is available online. We propose that our novel targeting system, and ever expanding cross-validation dataset, will be vital to the development of new algorithms for automatically detecting/sorting single-units, characterizing new electrode materials/designs, and resolving nagging questions regarding the origin and nature of extracellular neural signals.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Silicio
/
Potenciales de Acción
/
Electrofisiología
/
Microelectrodos
/
Red Nerviosa
/
Neuronas
Límite:
Animals
Idioma:
En
Revista:
J Neurophysiol
Año:
2016
Tipo del documento:
Article
País de afiliación:
Reino Unido