DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia.

Rau, Rachel E; Rodriguez, Benjamin A; Luo, Min; Jeong, Mira; Rosen, Allison; Rogers, Jason H; Campbell, Carly T; Daigle, Scott R; Deng, Lishing; Song, Yongcheng; Sweet, Steve; Chevassut, Timothy; Andreeff, Michael; Kornblau, Steven M; Li, Wei; Goodell, Margaret A

Rau, Rachel E; Rodriguez, Benjamin A; Luo, Min; Jeong, Mira; Rosen, Allison; Rogers, Jason H; Campbell, Carly T; Daigle, Scott R; Deng, Lishing; Song, Yongcheng; Sweet, Steve; Chevassut, Timothy; Andreeff, Michael; Kornblau, Steven M; Li, Wei; Goodell, Margaret A.

Afiliación

Rau RE; Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX; Dan L. Duncan Cancer Center.
Rodriguez BA; Dan L. Duncan Cancer Center, Department of Molecular and Cellular Biology.
Luo M; Department of Molecular and Human Genetics, Stem Cells and Regenerative Medicine Center, and Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX;
Jeong M; Department of Molecular and Human Genetics, Stem Cells and Regenerative Medicine Center, and Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX;
Rosen A; Department of Molecular and Human Genetics, Stem Cells and Regenerative Medicine Center, and Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX;
Rogers JH; Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX;
Campbell CT; Epizyme, Inc., Cambridge, MA;
Daigle SR; Epizyme, Inc., Cambridge, MA;
Deng L; Department of Pharmacology, Baylor College of Medicine, Houston, TX;
Song Y; Department of Pharmacology, Baylor College of Medicine, Houston, TX;
Sweet S; Genome Damage and Stability Centre, and.
Chevassut T; Department of Haematology, Brighton and Sussex Medical School, University of Sussex, Brighton, United Kingdom; and.
Andreeff M; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
Kornblau SM; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
Li W; Dan L. Duncan Cancer Center, Department of Molecular and Cellular Biology.
Goodell MA; Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX; Dan L. Duncan Cancer Center, Department of Molecular and Human Genetics, Stem Cells and Regenerative Medicine Center, and Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX;

Blood ; 128(7): 971-81, 2016 08 18.

Article en En | MEDLINE | ID: mdl-27335278

Asunto(s)

ADN (Citosina-5-)-Metiltransferasas/genética; Leucemia Mieloide Aguda/tratamiento farmacológico; Leucemia Mieloide Aguda/enzimología; Metiltransferasas/genética; Metiltransferasas/metabolismo; Terapia Molecular Dirigida; Mutación/genética; Adenosina/análogos & derivados; Adenosina/farmacología; Adenosina/uso terapéutico; Animales; Apoptosis; Puntos de Control del Ciclo Celular; Diferenciación Celular; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; ADN Metiltransferasa 3A; Regulación Leucémica de la Expresión Génica/efectos de los fármacos; Células Madre Hematopoyéticas/efectos de los fármacos; Células Madre Hematopoyéticas/metabolismo; N-Metiltransferasa de Histona-Lisina; Histonas/metabolismo; Humanos; Leucemia Mieloide Aguda/genética; Leucemia Mieloide Aguda/patología; Lisina/metabolismo; Metilación; Ratones Endogámicos C57BL; Compuestos de Fenilurea/farmacología; Compuestos de Fenilurea/uso terapéutico; Ratas; Factores de Tiempo; Ensayo de Tumor de Célula Madre; Ensayos Antitumor por Modelo de Xenoinjerto

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / ADN (Citosina-5-)-Metiltransferasas / Terapia Molecular Dirigida / Metiltransferasas / Mutación Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Blood Año: 2016 Tipo del documento: Article

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