Transient Receptor Potential Melastatin 2:an Ion Channel for Oxidative Stress Sensing.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
; 38(3): 364-7, 2016 06 10.
Article
en En
| MEDLINE
| ID: mdl-27469928
ABSTRACT
Transient receptor potential (TRP) channel is a superfamily of cation channels located on the cell membrane. TRP channels are classified into seven subfamilies based on the amino acid sequence homology,and transient receptor potential melastatin 2(TRPM2) is the second member of the TRPM subfamily. More evidences have revealed the important roles of TRPM2 in physiological and pathological events such as release of insulin from pancreatic Β-cells,inflammatory cytokines production from cells,and oxidative stress-induced cell death. As a cellular sensor for oxidative stress channel,TRPM2 is activated by a variety of factors. TRPM2 is a potential therapeutic target for oxidative stress-related diseases.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Estrés Oxidativo
/
Canales Catiónicos TRPM
Límite:
Humans
Idioma:
En
Revista:
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
Año:
2016
Tipo del documento:
Article
País de afiliación:
China