Histone deacetylase inhibitors induce invasion of human melanoma cells in vitro via differential regulation of N-cadherin expression and RhoA activity.

Díaz-Núñez, María; Díez-Torre, Alejandro; De Wever, Olivier; Andrade, Ricardo; Arluzea, Jon; Silió, Margarita; Aréchaga, Juan

Díaz-Núñez, María; Díez-Torre, Alejandro; De Wever, Olivier; Andrade, Ricardo; Arluzea, Jon; Silió, Margarita; Aréchaga, Juan.

Afiliación

Díaz-Núñez M; Laboratory of Stem Cells, Development & Cancer, Department of Cell Biology & Histology, Faculty of Medicine & Nursing, University of the Basque Country (UPV/EHU), Leioa, Biscay, Spain.
Díez-Torre A; Analytical & High Resolution Biomedical Microscopy Core Facility, University of the Basque Country (UPV/EHU), Leioa, Spain.
De Wever O; Laboratory of Experimental Cancer Research, Department of Radiotherapy and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium.
Andrade R; Analytical & High Resolution Biomedical Microscopy Core Facility, University of the Basque Country (UPV/EHU), Leioa, Spain.
Arluzea J; Laboratory of Stem Cells, Development & Cancer, Department of Cell Biology & Histology, Faculty of Medicine & Nursing, University of the Basque Country (UPV/EHU), Leioa, Biscay, Spain.
Silió M; Analytical & High Resolution Biomedical Microscopy Core Facility, University of the Basque Country (UPV/EHU), Leioa, Spain.
Aréchaga J; Laboratory of Stem Cells, Development & Cancer, Department of Cell Biology & Histology, Faculty of Medicine & Nursing, University of the Basque Country (UPV/EHU), Leioa, Biscay, Spain.

BMC Cancer ; 16: 667, 2016 08 22.

Article en En | MEDLINE | ID: mdl-27549189

Asunto(s)

Cadherinas/biosíntesis; Inhibidores de Histona Desacetilasas/farmacología; Melanoma/patología; Invasividad Neoplásica/patología; Proteína de Unión al GTP rhoA/metabolismo; Antineoplásicos/farmacología; Apoptosis/efectos de los fármacos; Butiratos/farmacología; Cadherinas/genética; Línea Celular Tumoral; Regulación Neoplásica de la Expresión Génica; Humanos; Ácidos Hidroxámicos/farmacología; Interferencia de ARN; ARN Interferente Pequeño/genética; Ácido Valproico/farmacología; Vorinostat

Palabras clave

Cell invasion; HDACi; Histone deacetylase inhibitors; Melanoma; N-cadherin; RhoA

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Cadherinas / Proteína de Unión al GTP rhoA / Inhibidores de Histona Desacetilasas / Melanoma / Invasividad Neoplásica Límite: Humans Idioma: En Revista: BMC Cancer Asunto de la revista: NEOPLASIAS Año: 2016 Tipo del documento: Article País de afiliación: España

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