TET-mediated DNA demethylation controls gastrulation by regulating Lefty-Nodal signalling.

Dai, Hai-Qiang; Wang, Bang-An; Yang, Lu; Chen, Jia-Jia; Zhu, Guo-Chun; Sun, Mei-Ling; Ge, Hao; Wang, Rui; Chapman, Deborah L; Tang, Fuchou; Sun, Xin; Xu, Guo-Liang

Dai, Hai-Qiang; Wang, Bang-An; Yang, Lu; Chen, Jia-Jia; Zhu, Guo-Chun; Sun, Mei-Ling; Ge, Hao; Wang, Rui; Chapman, Deborah L; Tang, Fuchou; Sun, Xin; Xu, Guo-Liang.

Afiliación

Dai HQ; State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; University of Chinese Academy of Sciences, Beijing 100049, Chi
Wang BA; Shanghai Key Laboratory of Molecular Andrology, Institute of Biochemistry and Cell Biology, Chinese Academy of Science, Shanghai 200031, China.
Yang L; State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; University of Chinese Academy of Sciences, Beijing 100049, Chi
Chen JJ; Shanghai Key Laboratory of Molecular Andrology, Institute of Biochemistry and Cell Biology, Chinese Academy of Science, Shanghai 200031, China.
Zhu GC; Biodynamic Optical Imaging Center, College of Life Sciences, Peking University, Beijing 100871, China.
Sun ML; Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Peking University, Beijing 100871, China.
Ge H; State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; University of Chinese Academy of Sciences, Beijing 100049, Chi
Wang R; Shanghai Key Laboratory of Molecular Andrology, Institute of Biochemistry and Cell Biology, Chinese Academy of Science, Shanghai 200031, China.
Chapman DL; State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; University of Chinese Academy of Sciences, Beijing 100049, Chi
Tang F; Shanghai Key Laboratory of Molecular Andrology, Institute of Biochemistry and Cell Biology, Chinese Academy of Science, Shanghai 200031, China.
Sun X; School of Life Science and Technology, ShanghaiTech University, Shanghai 200031, China.
Xu GL; Biodynamic Optical Imaging Center, College of Life Sciences, Peking University, Beijing 100871, China.

Nature ; 538(7626): 528-532, 2016 10 27.

Article en En | MEDLINE | ID: mdl-27760115

Asunto(s)

Metilación de ADN; Proteínas de Unión al ADN/metabolismo; Dioxigenasas/metabolismo; Gastrulación; Factores de Determinación Derecha-Izquierda/metabolismo; Proteína Nodal/metabolismo; Proteínas Proto-Oncogénicas/metabolismo; Transducción de Señal; 5-Metilcitosina/metabolismo; Animales; ADN (Citosina-5-)-Metiltransferasas/metabolismo; Metilación de ADN/genética; ADN Metiltransferasa 3A; Proteínas de Unión al ADN/deficiencia; Proteínas de Unión al ADN/genética; Dioxigenasas/deficiencia; Dioxigenasas/genética; Embrión de Mamíferos/embriología; Embrión de Mamíferos/enzimología; Embrión de Mamíferos/metabolismo; Elementos de Facilitación Genéticos/genética; Epigénesis Genética; Femenino; Gastrulación/genética; Masculino; Mesodermo/embriología; Mesodermo/metabolismo; Ratones; Oxidación-Reducción; Regiones Promotoras Genéticas/genética; Proteínas Proto-Oncogénicas/deficiencia; Proteínas Proto-Oncogénicas/genética; Transducción de Señal/genética; ADN Metiltransferasa 3B

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Transducción de Señal / Proteínas Proto-Oncogénicas / Metilación de ADN / Dioxigenasas / Proteínas de Unión al ADN / Gastrulación / Factores de Determinación Derecha-Izquierda / Proteína Nodal Límite: Animals Idioma: En Revista: Nature Año: 2016 Tipo del documento: Article

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