Fruit and vegetables consumption is directly associated to survival after prostate cancer.
Mol Nutr Food Res
; 61(4)2017 04.
Article
en En
| MEDLINE
| ID: mdl-27805317
ABSTRACT
SCOPE Since the evidence on the role of diet on prostate cancer (PCa) prognosis is still controversial, we evaluated the long-term effects of fruit and vegetables consumption on survival after PCa. METHODS AND RESULTS:
A retrospective cohort study included 777 men with PCa diagnosed between 1995 and 2002 in north-eastern Italy and followed up to 2013. A validated food frequency questionnaire assessed the usual diet in the 2 years before PCa diagnosis, including detailed fruit and vegetables consumption. Adjusted hazard ratios (HRs) of death with 95% confidence intervals (CIs) were estimated using Fine-Gray models. PCa patients with a consumption of both fruit and vegetables above the median showed a higher 15-year overall survival probability than those with lower intakes (71% versus 58%, p = 0.04; HR = 0.66, 95% CI 0.47-0.93). Consumption of foods rich in fiber (HR = 0.59, 95% CI 0.41-0.86) and proanthocyanidins (HR = 0.58, 95% CI 0.40-0.82) were inversely associated with overall mortality. Interestingly, proanthocyanidins (HR = 0.52; 95% CI 0.27-0.98) and flavonols (HR = 0.40; 95% CI 0.19-0.84) were inversely associated also with PCa-specific mortality.CONCLUSION:
High consumption of fruit and vegetables offers an advantage in survival among the rising number of men living after a PCa diagnosis, possibly through the epigenetic effect of some nutrients.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
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Sobrevida
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Verduras
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Frutas
Tipo de estudio:
Observational_studies
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Risk_factors_studies
Límite:
Aged
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Mol Nutr Food Res
Asunto de la revista:
CIENCIAS DA NUTRICAO
Año:
2017
Tipo del documento:
Article
País de afiliación:
Italia