Precuneal Thickness and Depression in Parkinson Disease.
Neurodegener Dis
; 17(2-3): 97-102, 2017.
Article
en En
| MEDLINE
| ID: mdl-27883992
ABSTRACT
BACKGROUND:
Depression-related gray matter changes in Parkinson disease (PD) patients have been reported, although studies investigating cortical thickness in early-stage disease are lacking.OBJECTIVE:
We aimed to evaluate cortical changes related to depression in early-stage PD patients with an extensive neuropsychological evaluation.METHODS:
17 PD patients and 22 healthy controls underwent a 1.5-T brain MR protocol, and voxel-wise differences in cortical thickness among patients with (n = 6) and without (n = 11) depression and controls were evaluated using FreeSurfer software.RESULTS:
Cortical thickness was increased in the precuneus bilaterally in PD patients with depression compared to the other groups (number of vertices >100; p < 0.001, uncorrected) with a direct correlation with the Beck Depression Inventory score (p < 0.001, uncorrected).CONCLUSION:
Precuneal cortical thickening is evident in PD patients with mild-moderate depression even in the early stages of the disease. This finding may reflect the early involvement of this region in the development of PD-related depression.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Lóbulo Parietal
/
Enfermedad de Parkinson
/
Depresión
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Neurodegener Dis
Asunto de la revista:
NEUROLOGIA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Italia