Proinflammatory cytokine interferon-Î³ and microbiome-derived metabolites dictate epigenetic switch between forkhead box protein 3 isoforms in coeliac disease.

Serena, G; Yan, S; Camhi, S; Patel, S; Lima, R S; Sapone, A; Leonard, M M; Mukherjee, R; Nath, B J; Lammers, K M; Fasano, A

Serena, G; Yan, S; Camhi, S; Patel, S; Lima, R S; Sapone, A; Leonard, M M; Mukherjee, R; Nath, B J; Lammers, K M; Fasano, A.

Afiliación

Serena G; Massachusetts General Hospital and Division of Pediatric Gastroenterology and Nutrition, Center for Celiac Research, Mucosal Immunology and Biology Research Center, Boston, MA, USA.
Yan S; Graduate Program in Life Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Camhi S; Massachusetts General Hospital and Division of Pediatric Gastroenterology and Nutrition, Center for Celiac Research, Mucosal Immunology and Biology Research Center, Boston, MA, USA.
Patel S; Massachusetts General Hospital and Division of Pediatric Gastroenterology and Nutrition, Center for Celiac Research, Mucosal Immunology and Biology Research Center, Boston, MA, USA.
Lima RS; Massachusetts General Hospital and Division of Pediatric Gastroenterology and Nutrition, Center for Celiac Research, Mucosal Immunology and Biology Research Center, Boston, MA, USA.
Sapone A; Massachusetts General Hospital and Division of Pediatric Gastroenterology and Nutrition, Center for Celiac Research, Mucosal Immunology and Biology Research Center, Boston, MA, USA.
Leonard MM; Massachusetts General Hospital and Division of Pediatric Gastroenterology and Nutrition, Center for Celiac Research, Mucosal Immunology and Biology Research Center, Boston, MA, USA.
Mukherjee R; Celiac Center, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Nath BJ; Massachusetts General Hospital and Division of Pediatric Gastroenterology and Nutrition, Center for Celiac Research, Mucosal Immunology and Biology Research Center, Boston, MA, USA.
Lammers KM; Celiac Center, Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Fasano A; Department of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA.

Clin Exp Immunol ; 187(3): 490-506, 2017 03.

Article en En | MEDLINE | ID: mdl-27936497

Asunto(s)

Enfermedad Celíaca/metabolismo; Citocinas/metabolismo; Epigénesis Genética/genética; Factores de Transcripción Forkhead/metabolismo; Inflamación/metabolismo; Interferón gamma/metabolismo; Microbiota/fisiología; Adolescente; Adulto; Anciano; Antígenos CD4/metabolismo; Enfermedad Celíaca/genética; Regulación hacia Abajo/genética; Femenino; Humanos; Inflamación/genética; Subunidad alfa del Receptor de Interleucina-2/metabolismo; Mucosa Intestinal/metabolismo; Intestino Delgado/metabolismo; Leucocitos Mononucleares/metabolismo; Masculino; Persona de Mediana Edad; Isoformas de Proteínas/metabolismo; Linfocitos T Reguladores/metabolismo; Células Th17/metabolismo; Adulto Joven

Palabras clave

Treg; autoimmunity; celiac disease; microbiome

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad Celíaca / Citocinas / Interferón gamma / Epigénesis Genética / Factores de Transcripción Forkhead / Microbiota / Inflamación Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Exp Immunol Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos

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