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Selection and early clinical evaluation of the brain-penetrant 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitor UE2343 (Xanamem™).
Webster, Scott P; McBride, Andrew; Binnie, Margaret; Sooy, Karen; Seckl, Jonathan R; Andrew, Ruth; Pallin, T David; Hunt, Hazel J; Perrior, Trevor R; Ruffles, Vincent S; Ketelbey, J William; Boyd, Alan; Walker, Brian R.
Afiliación
  • Webster SP; Centre for Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute, Edinburgh, UK.
  • McBride A; Centre for Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute, Edinburgh, UK.
  • Binnie M; Centre for Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute, Edinburgh, UK.
  • Sooy K; Centre for Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute, Edinburgh, UK.
  • Seckl JR; Centre for Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute, Edinburgh, UK.
  • Andrew R; Centre for Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute, Edinburgh, UK.
  • Pallin TD; Charles River Laboratories, Harlow, UK.
  • Hunt HJ; Corcept Therapeutics, Menlo Park, California, USA.
  • Perrior TR; Domainex Limited, Cambridge, UK.
  • Ruffles VS; Actinogen Medical Ltd, Sydney, New South Wales, Australia.
  • Ketelbey JW; Actinogen Medical Ltd, Sydney, New South Wales, Australia.
  • Boyd A; Alan Boyd Consultants Ltd, Crewe, UK.
  • Walker BR; Centre for Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute, Edinburgh, UK.
Br J Pharmacol ; 174(5): 396-408, 2017 03.
Article en En | MEDLINE | ID: mdl-28012176
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Tiofenos / Tropanos / Encéfalo / 11-beta-Hidroxiesteroide Deshidrogenasa de Tipo 1 / Inhibidores Enzimáticos Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adolescent / Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Br J Pharmacol Año: 2017 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Tiofenos / Tropanos / Encéfalo / 11-beta-Hidroxiesteroide Deshidrogenasa de Tipo 1 / Inhibidores Enzimáticos Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adolescent / Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Br J Pharmacol Año: 2017 Tipo del documento: Article País de afiliación: Reino Unido