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Wnt/ß-catenin signaling activates nephronectin expression in osteoblasts.
Ikehata, Mikiko; Yamada, Atsushi; Morimura, Naoko; Itose, Masakatsu; Suzawa, Tetsuo; Shirota, Tatsuo; Chikazu, Daichi; Kamijo, Ryutaro.
Afiliación
  • Ikehata M; Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan; Department of Oral and Maxillofacial Surgery, Tokyo Medical University, Tokyo, Japan.
  • Yamada A; Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan. Electronic address: yamadaa@dent.showa-u.ac.jp.
  • Morimura N; Department of Integrative Physiology, Shiga University of Medical Science, Shiga, Japan.
  • Itose M; Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan; Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University, Tokyo, Japan.
  • Suzawa T; Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan.
  • Shirota T; Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University, Tokyo, Japan.
  • Chikazu D; Department of Oral and Maxillofacial Surgery, Tokyo Medical University, Tokyo, Japan.
  • Kamijo R; Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan.
Biochem Biophys Res Commun ; 484(2): 231-234, 2017 03 04.
Article en En | MEDLINE | ID: mdl-28093227
ABSTRACT
Nephronectin (Npnt), an extracellular matrix protein, is considered to play critical roles as an adhesion molecule in the development and functions of various organs and tissues, such as the kidneys and bone. In the present study, we found that Wnt3a strongly enhanced Npnt mRNA expression in osteoblast-like MC3T3-E1 cells, while it also induced an increase in Npnt gene expression in both time- and dose-dependent manners via the Wnt/ß-catenin signaling pathway. These results suggest novel mechanisms for Wnt3a-induced osteoblast proliferation and cell survival via Npnt gene expression.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Osteoblastos / Transducción de Señal / Proteínas de la Matriz Extracelular / Beta Catenina / Proteína Wnt3A Límite: Animals Idioma: En Revista: Biochem Biophys Res Commun Año: 2017 Tipo del documento: Article País de afiliación: Japón
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Osteoblastos / Transducción de Señal / Proteínas de la Matriz Extracelular / Beta Catenina / Proteína Wnt3A Límite: Animals Idioma: En Revista: Biochem Biophys Res Commun Año: 2017 Tipo del documento: Article País de afiliación: Japón